A Certificate of Analysis (COA) is a third-party document that records the measured purity, identity, and quality parameters of a specific lot of a research compound. For research peptides, a complete COA includes an HPLC chromatogram, a mass spectrometry confirmation, and an endotoxin assay result, all tied to a specific lot number.
What Should Be on a Research-Grade COA
- Lot number — must match the lot printed on the vial label
- Compound name and full sequence (for peptides)
- HPLC chromatogram — the actual chart, not just a number
- Calculated purity %
- Mass spectrometry result — molecular weight within ≤2 Da of theoretical
- LAL endotoxin result — typically reported in EU/mg
- Manufacture date and shelf-life
- Lab name and signatory
Per-Lot vs. Generic Batch COAs
A “generic batch certificate” is one COA covering an entire production batch — it doesn’t tell you anything specific about the vial in your hand if your lot wasn’t the one tested.
A per-lot COA is independently tested for each lot before stock goes live. The lot number on the COA matches the lot number on your vial. This is the research-grade standard.
Where to Find Yours
Matte Protocol publishes per-lot COAs at matteprotocol.com/coas/, organized by lot number. If you need a specific lot before purchasing, email [email protected].
Research use only. Not for human consumption. Statements not evaluated by the US FDA.