IGF-1 LR3 (Long R3 IGF-1) is an 83-amino acid analog of insulin-like growth factor 1, incorporating an arginine substitution at position 3 and a 13-amino acid N-terminal extension peptide. These modifications, extensively documented in published biochemistry literature, reduce binding to IGF-binding proteins (IGFBPs), resulting in enhanced bioavailability in research assay systems.
The compound has been widely utilized in published cell biology and receptor pharmacology studies to investigate IGF-1 receptor (IGF-1R) signaling, including PI3K/Akt and MAPK/ERK pathway activation. Its reduced IGFBP interaction profile makes it particularly useful for studying receptor-level effects without the confounding variable of binding protein sequestration.
Each 1mg vial contains lyophilized IGF-1 LR3 with analytical verification of sequence integrity, biological activity, and chromatographic purity. Handle with appropriate laboratory precautions given the compound’s potent receptor-activating properties.
Exclusively for in-vitro and preclinical research. Not intended for human or veterinary use.
