5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine as a methyl donor. Published research has characterized NNMT’s role in regulating cellular NAD+ salvage pathway flux and one-carbon metabolism, positioning 5-Amino-1MQ as a tool compound for studying these interconnected metabolic networks.
The compound has been referenced in published studies examining NNMT’s involvement in adipocyte metabolism, cellular energy expenditure regulation, and SAM-dependent methylation dynamics. Researchers have documented 5-Amino-1MQ’s effects on intracellular NAD+ concentrations, NNMT enzymatic activity, and downstream metabolic gene expression in cell-based experimental systems.
Each 50mg vial contains analytically verified 5-Amino-1MQ suitable for enzymatic inhibition assays, metabolic flux studies, and cell culture applications. Purity and identity are confirmed through appropriate chromatographic and spectroscopic methods.
Intended solely for laboratory research. Not for human or veterinary use.
